Vaccination generates serum-mediated protection against Onchocerca lienalis microfilariae in the mouse
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BCG-Mediated Protection against Mycobacterium ulcerans Infection in the Mouse
BACKGROUND Vaccination with Mycobacterium bovis bacille Calmette-Guérin (BCG) is widely used to reduce the risk of childhood tuberculosis and has been reported to have efficacy against two other mycobacterial diseases, leprosy and Buruli ulcer caused by M. ulcerans (Mu). Studies in experimental models have also shown some efficacy against infection caused by Mu. In mice, most studies use the C5...
متن کاملSuccessful vaccination against Onchocerca ochengi infestation in cattle using live Onchocerca volvulus infective larvae.
Epidemiological evidence has led to the hypothesis that the concurrent and predominant transmission of Onchocerca ochengi by Simulium damnosum s.l. in sub-Saharan Africa could lead to the protection of humans against onchocerciasis caused by Onchocerca volvulus (zooprophylaxis). To gain support for this hypothesis, we investigated whether exposure to O. volvulus could protect cattle from O. och...
متن کاملThe major radioiodinated cuticular antigens of Onchocerca gibsoni microfilariae are neither species nor onchocerca specific.
The possible role of microfilarial surface (cuticular) antigens in immuno-diagnosis of human filarial infections has been assessed using microfilariae (mf) of the cattle parasite Onchocerca gibsoni. A Triton X-100 extract of 125I-labeled O. gibsoni mf was reacted with a panel of sera from humans infected with Onchocerca volvulus, Wuchereria bancrofti and Schistosoma japonicum as well as sera fr...
متن کاملScanning Electron Microscopy of Onchocerca volvulus Microfilariae from Guatemala
Microfilariae of Onchocerca volvulus from Guatemala were examined by scanning electron microscope. There are numerous transverse striations on the cuticular surface. The number of annulations varies from 325 to 357. The anterior end forms a round cephalic cap which bears a V-shaped hook. Two small openings are present on the cephalic cap. They are probably the openings of one of the amphidial c...
متن کاملMoulting and exsheathment of the infective larvae of Onchocerca lienalis (Filarioidea) in vitro.
Fourth-stage larvae (L4) of the cattle filarial parasite Onchocerca lienalis were produced from third stage forms (L3) and maintained in vitro using a variety of culture media and feeder cell layers. Up to 50% of the L3 larvae moulted to the fourth stage in the presence of two jird (Meriones unguiculatus) cell lines, a monkey kidney cell line and also with Vero cells. Moulting took place 2-5 da...
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ژورنال
عنوان ژورنال: Tropical Medicine and International Health
سال: 1996
ISSN: 1360-2276,1365-3156
DOI: 10.1046/j.1365-3156.1996.d01-48.x